twist or pull (something) sharply

he tweaked the boy's ear

improve (a mechanism or system) by making fine adjustments to it

engineers tweak the car's operating systems during the race

become or cause to become agitated or excited, typically from taking amphetamines or another stimulant

I just about went crazy yesterday—I was totally tweaking out

caffeine is a natural mood elevator but if you're stressed to begin with it can kind of tweak you out