The highest scoring word in Words With Friends is UNDERMINE with a total of 16 points.
Synonyms: erode, wear away, eat away at, chip away, undercut
Synonyms: subvert, sabotage, threaten, weaken, compromise, diminish, reduce, impair, mar, spoil, ruin, impede, hinder, damage, hurt, injure, cripple, disable, enfeeble, sap, shake