The highest scoring word in Words With Friends is UNSCRUPULOUS with a total of 24 points.
Synonyms: unprincipled, unethical, immoral, amoral, conscienceless, untrustworthy, shameless, reprobate, exploitative, corrupt, corrupted, dishonest, fraudulent, cheating, dishonourable, deceitful, devious, underhand, guileful, cunning, furtive, sly, wrongdoing, unsavoury, disreputable, improper, bad, evil, wicked, villainous, roguish, sinful, ignoble, degenerate, venal