The highest scoring word in Words With Friends is ADVERSE with a total of 12 points.
Synonyms: unfavourable, disadvantageous, inauspicious, unpropitious, unfortunate, unlucky, untimely, untoward, harmful, dangerous, injurious, detrimental, hurtful, deleterious, destructive, pernicious, disadvantageous, unfavourable, unfortunate, unhealthy, hostile, unfavourable, antagonistic, unfriendly, ill-disposed, negative, opposing, opposed, contrary, dissenting, inimical, antipathetic, at odds