The highest scoring word in Words With Friends is EXHAUST with a total of 17 points.
Synonyms: tire out, wear out, overtire, overtax, fatigue, weary, tire, drain, run someone into the ground, run someone ragged, enervate, sap, debilitate, prostrate, enfeeble, tiring, wearying, taxing, fatiguing, wearing, enervating, draining, sapping, debilitating
Synonyms: use up, run through, go through, consume, finish, deplete, expend, spend, dissipate, waste, squander, fritter away
Synonyms: smoke, vapour, gas, exhalation, exhaust, effluvium, pollution