The highest scoring word in Words With Friends is DOLEFUL with a total of 14 points.
Synonyms: mournful, woeful, sorrowful, sad, unhappy, depressed, dismal, gloomy, morose, melancholy, miserable, forlorn, wretched, woebegone, despondent, dejected, disconsolate, downcast, crestfallen, downhearted, heartbroken, heavy-hearted, despairing, desolate, grief-stricken