The highest scoring word in Words With Friends is SPECKLE with a total of 18 points.
Synonyms: dot, pinprick, spot, fleck, speckle, stain, mark, smudge, blemish
Synonyms: flecked, speckly, specked, freckled, freckly, spotted, spotty, dotted, stippled, sprinkled, mottled, dappled, blotchy, brindled