The highest scoring word in Words With Friends is ASTUTE with a total of 7 points.
Synonyms: shrewd, sharp, sharp-witted, razor-sharp, acute, quick, quick-witted, ingenious, clever, intelligent, bright, brilliant, smart, canny, media-savvy, intuitive, discerning, perceptive, perspicacious, penetrating, insightful, incisive, piercing, discriminating, sagacious, wise, judicious