The highest scoring word in Words With Friends is UNPREDICTABLE with a total of 26 points.
Synonyms: unforeseeable, undivinable, incalculable, uncertain, unsure, doubtful, dubious, in the balance, up in the air, random, arbitrary, erratic, moody, volatile, unstable, fickle, capricious, whimsical, temperamental, mercurial, changeable, variable, inconstant, undependable, unreliable, unmanageable, impulsive