The highest scoring word in Words With Friends is UPSIDEDOWN with a total of 20 points.
Synonyms: upturned, upended, bottom up, wrong side up, head over heels, inverted, reversed, overturned, capsized, upset, flipped
Synonyms: upturned, upended, bottom up, wrong side up, head over heels, inverted, reversed, overturned, capsized, upset, flipped