The highest scoring word in Words With Friends is WEAKNESS with a total of 16 points.
Synonyms: frailty, feebleness, enfeeblement, puniness, fragility, delicateness, delicacy, weakliness, spinelessness, timidity, cravenness, cowardliness, pusillanimity, timorousness, indecisiveness, indecision, irresolution, ineffectuality, uselessness, ineptness, ineptitude, effeteness, meekness, tameness, powerlessness, ineffectiveness, impotence, faint-heartedness, inadequacy, defectiveness, faultiness, deficiency, imperfection, unconvincingness, untenability, tenuousness, implausibility, unsatisfactoriness, slightness, poverty, inadequacy, thinness, transparency, indistinctness, muffledness, mutedness, faintness, lowness, low intensity
Synonyms: fault, flaw, defect, deficiency, weak point/spot, failing, foible, shortcoming, imperfection, blemish, Achilles heel, chink in one's armour