The highest scoring word in Words With Friends is WRATHFUL with a total of 18 points.
Synonyms: angry, irate, raging, enraged, incensed, infuriated, furious, choleric, fuming, ranting, raving, rageful, seething, frenzied, in a frenzy, beside oneself, indignant, outraged, vexed, in high dudgeon, exasperated, in a temper, irritated, provoked, piqued, cross, displeased