The highest scoring word in Words With Friends is INVALIDATE with a total of 17 points.
Synonyms: disprove, show/prove to be false, refute, explode, contradict, rebut, negate, gainsay, belie, give the lie to, discredit, expose, debunk, knock the bottom out of, drive a coach and horses through
Synonyms: render invalid, void, nullify, annul, negate, cancel, quash, veto, overturn, overrule, override, undo, reverse